ea0032p464 | Diabetes | ECE2013
Ma Zhulin
, Christiansen Jens Sandahl
, Lauritzen Torsten
, Parkner Tina
, Laursen Torben
, Frystyk Jan
Introduction: Type 1 diabetes (T1D) is characterized by primary insulin insufficiency and secondary disruption of GHIGFIGFBP axis. S.c. insulin therapy is necessary to normalize this axis. This study aimed to investigate whether the distinct insulin profiles obtained with insulin aspart and human insulin preparations, respectively, affect IGF1 concentration and bioactivity and IGFBP levels differently.Methods: In a randomized, four-period cro...